ProSa 2003

ProSa 2003 is the succesor of ProSa-II, our software tool for the analysis of 3D structures of proteins. Making use of knowledge-based potentials, the program generates scores reflecting the quality of protein structures. These potentials are derived from known protein structures, capturing the average properties of native globular proteins in terms of atom-pair, and protein-solvent interactions. The program also provides graphs which pinpoint problematic sections in a particular structure. ProSa 2003 comes with updated knowledge-based potentials, an enhanced PDB parser, a command line history, and with a set of new commands that support in silico mutagenesis. Researchers throughout the world use ProSa as a valuable tool for protein modeling and experimental structure determination.

ProSa 2003 is successfully applied for:
	protein modeling
	protein engineering and in silico mutagenesis
	error detection in X-ray crystallography
	evaluation of NMR-derived protein models
	family-specific analysis of protein structures

Platform availability:
	Linux
		Suse
		Red Hat
	Windows 2000/XP